Edetic acid

Edetic acid - Names and Identifiers

Name	Ethylenediaminetetraacetic acid
Synonyms	EDTA EDTA ACID Edetic acid EDTA-SOLUTION Ethylenediaminetetraacetic acid Ethylene diamine tetraacetic acid EDTA, 500 mM Solution, pH 8.0,ULTROL Grade 3,4-diamino-3,4-bis(carboxymethyl)hexanedioic acid EDTA, free acid Ethylenediamine tetraacetic acid, free acid 2,2'-{ethane-1,2-diylbis[(carboxymethyl)imino]}diacetate (non-preferred name)
CAS	60-00-4
EINECS	200-449-4
InChI	InChI=1/C10H16N2O8/c11-9(1-5(13)14,2-6(15)16)10(12,3-7(17)18)4-8(19)20/h1-4,11-12H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20)

Edetic acid - Physico-chemical Properties

Molecular Formula	C10H16N2O8
Molar Mass	292
Density	1.628g/cm³
Melting Point	237-245℃ (dec.)
Boling Point	540.597°C at 760 mmHg
Flash Point	280.743°C
Water Solubility	0.5 g/L (25℃)
Solubility	The solubility in water at 25 ℃ is 0.5g/L. Insoluble in cold water, alcohols and general organic solvents. Soluble in sodium hydroxide, sodium carbonate and ammonia solution.
Vapor Presure	0mmHg at 25°C
Appearance	White crystal
Storage Condition	Room Temprature
Refractive Index	1.603
MDL	MFCD00003541
Physical and Chemical Properties	The character crystallized from water is white powder. solubility the solubility in water at 25 °c was 0.5g/L. Insoluble in cold water, alcohol and general organic solvents. Soluble in sodium hydroxide, sodium carbonate and ammonia solution.
Use	Used as dyeing aids, fiber treatment agents, cosmetic additives, blood anticoagulants, water treatment agents, rubber polymerization initiators, PVC heat stabilizers

Edetic acid - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection

Edetic acid - Upstream Downstream Industry

Raw Materials	Methyl alcohol Formaldehyde Sulfuric acid Chloroacetic acid Sodium hydroxide Hydrochloric acid Chloroacetic acid Ethylenediamine
Downstream Products	edta iron(iii) sodium salt Ethylenediaminetetraacetic acid disodium salt Ethylenediaminetetraacetic acid L-Tyrosine

Edetic acid - Reference

Reference

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3. Zhang ningying, Chen Haiyan, Chen Hangjun. Effects of Ozone treatment on storage quality and antioxidant enzyme activities of blueberry [J]. Chinese Journal of Food Science, 2017, 17(008):170-176.
4. Li Tong, Zhao Na, Shi Yu, et al. Formulation optimization and percutaneous permeability of vitamin C Nanoemulsion [J]. Journal of Shenyang Pharmaceutical University, 2018(7).
5. Mihanbao, Lijun. Study on the difference of antioxidant activity of different cocoon color silk enzymatic hydrolysis products [J]. Agricultural science research 2017(3).
6. He, Baoshan, et al. "Aptamer-based thin film gold electrode modified with gold nanoparticles and carboxylated multi-walled carbon nanotubes for detecting oxytetracycline in chicken samples." Food chemistry 300 (2019): 125179.https://doi.org/10.1016/j.foodc
7. Aitang Zhang, Aihua Li, Wei Zhao, Guowen Yan, Bingping Liu, Mengli Liu, Meixiu Li, Bingbing Huo Jingquan Liu,An efficient and self-guided chemo-photothermal drug loading system based on copolymer and transferrin decorated MoS2 nanodots for dually control
8. Aitang Zhang, Aihua Li, Wei Zhao, Guowen Yan, Bingping Liu, Mengli Liu, Meixiu Li, Bingbing Huo Jingquan Liu,An efficient and self-guided chemo-photothermal drug loading system based on copolymer and transferrin decorated MoS2 nanodots for dually control
9. Zhang, Aitang, et al. "A Target‐Directed Chemo‐Photothermal System Based on Transferrin and Copolymer‐Modified MoS2 Nanoplates with pH‐Activated Drug Release." Chemistry-A European Journal 23.47 (2017): 11346-11356.https://doi.org/10.1002/chem.201701916
10. Yang, Hui, et al." Intestinal absorption mechanisms of araloside A in situ single-pass intestinal perfusion and in vitro Caco-2 cell model." Biomedicine & Pharmacotherapy 106 (2018): 1563-1569.https://doi.org/10.1016/j.biopha.2018.07.117
11. Li, Guozhuan, et al. "Comparison of the chromatographic fingerprint, multicomponent quantitation and antioxidant activity of Salvia miltiorrhiza Bge. between sweating and nonsweating." Biomedical Chromatography 32.6 (2018): e4203.https://doi.org/10.1002/bm
12. Zhang, Li‐Ping, et al. "Effects of 1‐methylcyclopropene on the Metabolic Pathways of Aroma‐Related Compounds in N anguo Pear." Journal of Food Processing and Preservation 38.4 (2014): 1749-1758.https://doi.org/10.1111/jfpp.12138
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15. [IF=4.759] Liai Lan et al."Fast and direct determination of catechol-3, 6-bis(methyleiminodiacetic acid) prototype in beagle dog plasma using liquid chromatography tandem mass spectrometry: A simplified and high throughput in-vivo method for the metal chelator."J Ch
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18. [IF=2.19] Li-Ping Zhang et al."Effects of 1-methylcyclopropene on the Metabolic Pathways of Aroma-Related Compounds in Nanguo Pear."J Food Process Pres. 2014 Aug;38(4):1749-1758
19. [IF=1.902] Guozhuan Li et al."Comparison of the chromatographic fingerprint, multicomponent quantitation and antioxidant activity of Salvia miltiorrhiza Bge. between sweating and nonsweating."Biomed Chromatogr. 2018 Jun;32(6):e4203
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Edetic acid - Nature

Open Data Verified Data

white crystalline powder. mp240 ~ 241 deg C (decomposition). Soluble in sodium hydroxide, sodium carbonate and ammonia, insoluble in general organic solvents. The solubility in water was 0.2g/10 og at 20 °c. When the temperature reached 150 °c, the carboxyl group was removed.

Last Update：2025-06-10 22:55:16

Edetic acid - Preparation Method

Open Data Verified Data

In ethylenediaminetetraacetic acid and water, with stirring, add 30% sodium hydroxide solution, heat to complete reaction, add hydrochloric acid to pH 4.5, concentrate, filter, cool crystallization, wash, ethylenediaminetetraacetic acid was obtained by drying.

Last Update：2025-06-10 22:55:16

Edetic acid - Introduction

Soluble in sodium hydroxide, sodium carbonate and ammonia solution, soluble in 161 boiling water, slightly soluble in cold water, insoluble in alcohol and general organic solvents.

Last Update：2022-10-16 17:26:53

Edetic acid - Application

Open Data Verified Data

complexing reagent. It is used as a masking agent for metal ion complexing agent and separation, detergent, blood anticoagulant and agricultural chemical spray.

Last Update：2025-08-19 16:24:40

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